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Martha E O'Donnell Selected Research

Bumetanide (Bumex)

1/2021High glucose-induced effects on Na+-K+-2Cl- cotransport and Na+/H+ exchange of blood-brain barrier endothelial cells: involvement of SGK1, PKCĪ²II, and SPAK/OSR1.
1/2019Exacerbated brain edema in a rat streptozotocin model of hyperglycemic ischemic stroke: Evidence for involvement of blood-brain barrier Na-K-Cl cotransport and Na/H exchange.
5/2014Ischemic factor-induced increases in cerebral microvascular endothelial cell Na/H exchange activity and abundance: evidence for involvement of ERK1/2 MAP kinase.
2/2013Intravenous HOE-642 reduces brain edema and Na uptake in the rat permanent middle cerebral artery occlusion model of stroke: evidence for participation of the blood-brain barrier Na/H exchanger.
2/2012Ischemia-induced stimulation of cerebral microvascular endothelial cell Na-K-Cl cotransport involves p38 and JNK MAP kinases.
7/2011Effects of estradiol on ischemic factor-induced astrocyte swelling and AQP4 protein abundance.
3/2010Cerebral metabolic alterations in rats with diabetic ketoacidosis: effects of treatment with insulin and intravenous fluids and effects of bumetanide.
8/2009Cerebral microvascular endothelial cell Na/H exchange: evidence for the presence of NHE1 and NHE2 isoforms and regulation by arginine vasopressin.
10/2008Cerebral blood flow and cerebral edema in rats with diabetic ketoacidosis.
10/2006Estradiol reduces activity of the blood-brain barrier Na-K-Cl cotransporter and decreases edema formation in permanent middle cerebral artery occlusion.
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Martha E O'Donnell Research Topics

Disease

16Edema (Dropsy)
01/2021 - 01/2004
13Brain Edema (Cerebral Edema)
01/2019 - 09/2004
12Ischemia
05/2014 - 09/2004
11Stroke (Strokes)
01/2021 - 01/2004
10Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome)
01/2021 - 09/2004
10Ischemic Stroke
01/2019 - 01/2008
8Infarction (Infarctions)
01/2021 - 09/2004
8Hypoxia (Hypoxemia)
05/2014 - 12/2005
5Brain Ischemia (Cerebral Ischemia)
02/2013 - 09/2004
3Diabetic Ketoacidosis (Ketoacidosis, Diabetic)
02/2022 - 02/2005
1Hyperglycemia
01/2019
1Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage)
02/2012
1Dehydration (Water Stress)
10/2008

Drug/Important Bio-Agent (IBA)

13Bumetanide (Bumex)FDA LinkGeneric
01/2021 - 09/2004
12Sodium-Potassium-Chloride SymportersIBA
02/2013 - 09/2004
9Phenobarbital (Luminal)FDA Link
05/2014 - 01/2004
8CME-Carbodiimide (CMEC)IBA
01/2019 - 12/2005
6cariporideIBA
01/2021 - 08/2009
5Arginine Vasopressin (Argipressin)IBA
02/2013 - 08/2005
4Sodium-Hydrogen ExchangersIBA
02/2013 - 01/2008
3Proteins (Proteins, Gene)FDA Link
01/2015 - 12/2005
3Glucose (Dextrose)FDA LinkGeneric
08/2011 - 01/2008
3Estradiol (Delestrogen)FDA LinkGeneric
07/2011 - 10/2006
2IonsIBA
01/2021 - 05/2014
2Streptozocin (Streptozotocin)FDA Link
01/2019 - 02/2005
2TRAM 34IBA
01/2015 - 12/2011
2Oxygen (Dioxygen)IBA
08/2011 - 07/2011
2Adenosine Triphosphatases (ATPase)IBA
12/2005 - 01/2004
1ChemokinesIBA
02/2022
1LigandsIBA
02/2022
1SB 239063IBA
02/2012
1Phosphotransferases (Kinase)IBA
02/2012
1CalciumIBA
12/2011
1Eosine Yellowish-(YS) (Eosin)IBA
12/2011
1Hematoxylin (Haematoxylon)IBA
12/2011
1dorsomorphinIBA
08/2011
1Adenylate KinaseIBA
08/2011
1AMP-Activated Protein KinasesIBA
08/2011
1Insulin (Novolin)FDA Link
03/2010
1Coloring Agents (Dyes)IBA
08/2009
12',7'- bis(carboxyethyl)- 5(6)- carboxyfluoresceinIBA
08/2009
1NitrogenIBA
10/2008
1Urea (Carbamide)FDA LinkGeneric
10/2008
1Sucrose (Saccharose)IBA
01/2008
1Estrogens (Estrogen)FDA Link
10/2006
1triphenyltetrazoliumIBA
10/2006
1Adenosine Triphosphate (ATP)IBA
12/2005

Therapy/Procedure

1Intravenous Administration
02/2013